Since 2001, Cleber has investigated the role of neurotransmitters in neural physiology and development. Using human neural stem cells as model systems he explored novel pathways and therapeutic targets for neurodevelopmental disorders. As an Associate Project Scientist at the University of California San Diego, he took advantage of reprogramming technologies to generate iPSCs to recapitulate early stages of the human MECP2 Duplication Syndrome and Williams Syndrome. He also developed human cortical organoids that dynamically change cellular populations during maturation and exhibited consistent increases in electrical activity over the span of several months. The oscillatory activity transitioned to more spatiotemporally irregular patterns, while synchronous network events resembled features similar to those observed in preterm human electroencephalography. Recently, Cleber is developing the first functional phenotypic high throughput screening for CDD using iPS-derived neurons.